- Thyroid
- Thyroid Function across the Lifespan: Do Age-Related Changes Matter?
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John P. Walsh
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Endocrinol Metab. 2022;37(2):208-219. Published online April 14, 2022
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DOI: https://doi.org/10.3803/EnM.2022.1463
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 Abstract
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- Circulating concentrations of thyrotropin (TSH) and thyroxine (T4) are tightly regulated. Each individual has setpoints for TSH and free T4 which are genetically determined, and subject to environmental and epigenetic influence. Pituitary-thyroid axis setpoints are probably established in utero, with maturation of thyroid function continuing until late gestation. From neonatal life (characterized by a surge of TSH and T4 secretion) through childhood and adolescence (when free triiodothyronine levels are higher than in adults), thyroid function tests display complex, dynamic patterns which are sexually dimorphic. In later life, TSH increases with age in healthy older adults without an accompanying fall in free T4, indicating alteration in TSH setpoint. In view of this, and evidence that mild subclinical hypothyroidism in older people has no health impact, a strong case can be made for implementation of age-related TSH reference ranges in adults, as is routine in children.
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Citations
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Evie van der Spoel, Nicolien A van Vliet, Rosalinde K E Poortvliet, Robert S Du Puy, Wendy P J den Elzen, Terence J Quinn, David J Stott, Naveed Sattar, Patricia M Kearney, Manuel R Blum, Heba Alwan, Nicolas Rodondi, Tinh-Hai Collet, Rudi G J Westendorp,
The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1167. CrossRef - Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
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The Journal of Clinical Endocrinology & Metabolism.2023; 108(3): 604. CrossRef - A Causality between Thyroid Function and Bone Mineral Density in Childhood: Abnormal Thyrotropin May Be Another Pediatric Predictor of Bone Fragility
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Thyroid®.2023; 33(9): 1013. CrossRef - Blood hormones and suicidal behaviour: A systematic review and meta-analysis
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Neuroscience & Biobehavioral Reviews.2022; 139: 104725. CrossRef
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